Chinese | English  
Servicebio

TEL

+86 (0) 27 5111 3188

Polyclonals

  1. Home
  2. Products
  3. Primary antibodies
  4. Polyclonals
  5. Content

Anti -MEK4 Rabbit pAb

Cat. No. GB11691

Brand:servicebio

Price:230.00

Specification: 100μl

Download Attachment Files
Attachment Download Address: ×
/e/DownSys/DownSoft/?classid=19&id=785&pathid=0

Product Information

 

 

Description

MEK4 rabbit polyclona

Protein full name

Dual specificity mitogen-activated protein kinase kinase 4

Synonyms

MAP2K4, JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1, mitogen-activated protein kinase kinase 4, JNK activating kinase 1, c-Jun N-terminal kinase kinase 1

Immunogen

Recombinant protein corresponding to Mouse MEK4

Isotype IgG
Purity Affinity purification

Predicted MW.

44 kDa

Observed MW.

44 kDa

Uniprot ID

P45985, P47809

 


 

Applications

 

 

Applications

WB

Species

Human, Mouse, Rat

Dilution

1: 500-1: 1000

Positive tissue

pneumonia, splenitis, thymus

 


 

Background

 

 

Dual specificity mitogen-activated protein kinase kinase 4 is an enzyme that in humans is encoded by the MAP2K4 gene. This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK1. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.

        


 

Images

 

 

上传-2.jpg  

Western blot analysis of MEK4 (GB11691) at dilution of 1: 1000

 

Lane 1: 293T cell lysate

Lane 2: NIH/3T3 cell lysate

Lane 3: Raw264.7 cell lysate

Lane 4: Mouse liver tissue lysate

Lane 5: Mouse brain tissue lysate

Lane 6: Mouse spinal cord tissue lysate

Lane 7: Rat liver tissue lysate

Lane 8: Rat brain tissue lysate

 Lane 9: Rat spinal cord tissue lysate

 


 

Storage

 

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.