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Anti -PPP1CB Rabbit pAb

Cat. No. GB111163

Brand:Servicebio

Price:230

Specification: 100μl

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Product Information

 

Description

PPP1CB rabbit polyclonal

Protein full name

Serine/threonine-protein phosphatase PP1-beta catalytic subunit

Synonyms

PP-1B, Ppp1cb

Immunogen

Recombinant protein corresponding to Mouse PPP1CB

Isotype IgG
Purity Affinity purification

Predicted MW.

37 kDa

Observed MW.

37 kDa

Uniprot ID

P62140, P62141, P62142

 


 

Applications

 

Applications

WB

Species

Human, Mouse, Rat

Dilution

1: 500-1: 1000

Positive tissue

cerebellum, brain

 


 

Background

 

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective.
 


 

Images

 

Western blot analysis of PPP1CB (GB111163) at dilution of 1: 1000

Lane 1: Hela cell lysate

Lane 2: 293T cell lysate

Lane 3: Mouse cerebellum tissue lysate

Lane 4: Rat brain tissue lysate

Lane 5: Rat cerebellum tissue lysate

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.

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