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Anti -MDM2 Rabbit pAb

Cat. No. GB111161

Brand:Servicebio

Price:230

Specification: 100μl

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Product Information

 

Description

MDM2 rabbit polyclonal

Protein full name
E3 ubiquitin-protein ligase Mdm2

Synonyms

Double minute 2 protein, Oncoprotein Mdm2, RING-type E3 ubiquitin transferase Mdm2, p53-binding protein Mdm2

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse MDM2

Isotype IgG
Purity Affinity purification
Subcellular location

Nucleus, Cytoplasm

Uniprot ID

P23804

 


 

Applications

 

Applications

IHC

Species

Mouse, Rat

Dilution

1: 1000-1: 2000

Positive tissue

lung, kidney, thymus

 


 

Background

 

MDM2 is a target of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of MDM2 can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle,apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5.
 


 

Images

 

Immunohistochemistry analysis of paraffin-embedded mouse lung using MDM2 (GB111161) at dilution of 1: 1500
 

   

Immunohistochemistry analysis of paraffin-embedded rat lung using DM2 (GB111161) at dilution of 1: 1500
 

   

Immunohistochemistry analysis of paraffin-embedded mouse kidney using MDM2 (GB111161) at dilution of 1: 1500
 

   

Immunohistochemistry analysis of paraffin-embedded rat kidney using MDM2 (GB111161) at dilution of 1: 1500
 

   

Immunohistochemistry analysis of paraffin-embedded mouse thymus using MDM2 (GB111161) at dilution of 1: 1500

 

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.

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