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Anti -RNF8 Rabbit pAb

Cat. No. GB111158

Brand:Servicebio

Price:230

Specification: 100μl

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Product Information

 

Description

RNF8 rabbit polyclonal

Protein full name
E3 ubiquitin-protein ligase RNF8

Synonyms

ActA-interacting protein 37, AIP37, LaXp180, RING finger protein 8, Rnf8, RING-type E3 ubiquitin transferase RNF8 

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse RNF8

Isotype IgG
Purity Affinity purification

Predicted MW.

56 kDa

Observed MW.

56 kDa

Uniprot ID

Q8VC56, Q4KLN8

 


 

Applications

 

Applications

WB

Species

Mouse, Rat

Dilution

1: 500-1: 1000

Positive tissue

brain

 


 

Background

 

The RNF8 (also named as KIAA0646 or E3 ubiquitin-protein ligase RNF8) contains one RING-type zinc finger and one FHA domain. RNF8 localizes in the nucleus and belongs to the RNF8 family. E2-E3 ubiquitin ligase complex is composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites.
 


 

Images

 

Western blot analysis of RNF8 (GB111158) at dilution of 1: 1000
Lane 1: Mouse brain tissue lysate
Lane 2: Rat brain tissue lysate
 

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.

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