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Anti -VCP Rabbit pAb

Cat. No. GB111155

Brand:Servicebio

Price:230

Specification: 100μl

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Product Information

 

Description

VCP rabbit polyclonal

Protein full name
Transitional endoplasmic reticulum ATPase

Synonyms

TER ATPase, 15S Mg(2+)-ATPase p97 subunit, Valosin-containing protein, VCP

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse VCP

Isotype IgG
Purity Affinity purification

Predicted MW.

89 kDa

Observed MW.

97 kDa

Uniprot ID

P55072, Q01853

 


 

Applications

 

Applications

WB

Species

Human, Mouse

Dilution

1: 500-1: 1000

Positive tissue

brain, lung

 


 

Background

 

Valosin-containing protein (VCP or p97) belongs to the AAA (ATPase associated activities) family and acts as a molecular chaperone to a wide variety of cellular activities. Some of these activities include the alteration of both nuclear and mitotic golgi membranes, ubiquitin-proteasome dependent protein degradation, regulation of the NF-kappa b pathway, and extraction of membrane proteins. VCP has been shown to contain a substrate binding domain (N) and two conserved ATPase domains (D1 and D2). The three dimensional structure of VCP resembles that of a cylinder with the D1 and D2 stacked upon one another in a homo-hexameric ring formation. VCP is involved in the formation of neuronal inclusion bodies in neurodegenerative disease such as Parkinson's Disease. VCP has a calculated molecular weight of 89 kDa and an apparent molecular weight of 90-100 kDa.
 


 

Images

 

Western blot analysis of VCP (GB111155) at dilution of 1: 1000
Lane 1: Hela cell lysate
Lane 2: K562 cell lysate
Lane 3: NIH/3T3 cell lysate
Lane 4: HT29 cell lysate
Lane 5: MDA-MB-231 cell lysate
Lane 6: Mouse brain tissue lysate
Lane 7: Mouse lung tissue lysate
 

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.

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