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Anti -Chk1 Rabbit pAb

Cat. No. GB111146

Brand:Servicebio

Price:230

Specification: 100μl

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Product Information

 

Description

Chk1 rabbit polyclonal

Protein full name Serine/threonine-protein kinase Chk1
 

Synonyms

CHK1 checkpoint homolog, Checkpoint kinase-1, Chek1, Chk1

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse Chk1

Isotype IgG
Purity Affinity purification
Subcellular location

Nucleus, Cytoplasm

Uniprot ID

Q91ZN7

 


 

Applications

 

Applications

IHC

Species

Rat

Dilution

1: 600-1: 1200

Positive tissue

lung, spleen, brain

 


 

Background

 

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks.
 


 

Images

 

Immunohistochemistry analysis of paraffin-embedded rat lung using Chk1 (GB111146) at dilution of 1: 650
 

   

Immunohistochemistry analysis of paraffin-embedded rat spleen using Chk1 (GB111146) at dilution of 1: 650
 

   

Immunohistochemistry analysis of paraffin-embedded rat brain using Chk1 (GB111146) at dilution of 1: 650
 

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.

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