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Anti -Clusterin Rabbit pAb

Cat. No. GB111144

Brand:Servicebio

Price:230

Specification: 100μl

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Product Information

 

Description

Clusterin rabbit polyclonal

Protein full name
Clusterin

Synonyms

Apolipoprotein J, Apo-J, Clustrin, Sulfated glycoprotein 2, SGP-2, Apoj, Clu

Immunogen

Recombinant protein corresponding to Mouse Clusterin

Isotype IgG
Purity Affinity purification
Subcellular location

Cytoplasm, NucleusSecreted

Uniprot ID

Q06890, P05371

 


 

Applications

 

Applications

IHC

Species

Mouse, Rat

Dilution

1: 500-1: 1000

Positive tissue

lung, ovary, pancreas

 


 

Background

 

The Clusterin functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins (By similarity).When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Modulates NF-kappa-B transcriptional activity. Following stress, promotes apoptosis . Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation. Following ER stress, suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5. When secreted, does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity. When secreted, acts as an important modulator during neuronal differentiation through interaction with STMN3. Plays a role in the clearance of immune complexes that arise during cell injury.
 


 

Images

 

Immunohistochemistry analysis of paraffin-embedded mouse lung using Clusterin (GB111144) at dilution of 1: 900
 

   

Immunohistochemistry analysis of paraffin-embedded rat lung using Clusterin (GB111144) at dilution of 1: 900
 

   

Immunohistochemistry analysis of paraffin-embedded mouse ovary using Clusterin (GB111144) at dilution of 1: 900
 

   

Immunohistochemistry analysis of paraffin-embedded mouse pancreas using Clusterin (GB111144) at dilution of 1: 900
 

   

Immunohistochemistry analysis of paraffin-embedded rat pancreas using Clusterin (GB111144) at dilution of 1: 900

 

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.

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