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Anti -BRCA2 Rabbit pAb

Cat. No. GB111138

Brand:Servicebio

Price:230

Specification: 100μl

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Product Information

 

Description

BRCA2 rabbit polyclonal

Protein full name
Breast cancer type 2 susceptibility protein
 

Synonyms

Fanconi anemia group D1 protein, BRCA2, FACD, FANCD1

Immunogen

Recombinant protein corresponding to Mouse BRCA2

Isotype IgG
Purity Affinity purification
Subcellular location

CytoplasmNucleus

Uniprot ID

P51587, P97929, O35923

 


 

Applications

 

Applications

IHC

IF

Species

Mouse, Rat

Mouse, Rat

Dilution

1: 1500-1: 3000

1: 1500-1: 3000

Positive tissue

brain

brain

 


 

Background

BRCA2, also named as FACD and FANCD1, is involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures.Defects in BRCA2 are a cause of genetic susceptibility to breast cancer (BC) which also called susceptibility to familial breast-ovarian cancer type 2 (BROVCA2).
 


 

Images

 

Immunohistochemistry analysis of paraffin-embedded mouse brain using BRCA2 (GB111138) at dilution of 1: 2200
 

   

Immunohistochemistry analysis of paraffin-embedded rat brain using BRCA2 (GB111138) at dilution of 1: 2200
 

   

Immunofluorescent analysis of paraffin-embedded mouse brain using BRCA2 (GB111138) at dilution of 1: 2200
 

   

Immunofluorescent analysis of paraffin-embedded rat brain using BRCA2 (GB111138) at dilution of 1: 2200
 

   

Immunofluorescent analysis of paraffin-embedded mouse brain using BRCA2 (GB111138) at dilution of 1: 2200

 

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.

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