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Anti -PFKL Rabbit pAb

Cat. No. GB111136

Brand:Servicebio

Price:230

Specification: 100μl

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Product Information

 

Description

PFKL rabbit polyclonal

Protein full name

ATP-dependent 6-phosphofructokinase, liver type

Synonyms

ATP-PFK, PFK-L, PFK-B, PFKL, 6-phosphofructokinase type B, Phosphofructo-1-kinase isozyme B

Immunogen

Recombinant protein corresponding to Human PFKL

Isotype IgG
Purity Affinity purification
Subcellular location

Cytoplasm

Uniprot ID

P17858

 


 

Applications

 

Applications

IHC

Species

Human

Dilution

1: 1000-1: 2000

Positive tissue

liver cancer, prostate

 


 

Background

 

PFKL is the Liver isozyme of PFK (Phosphofructokinase), which is a tetrameric enzyme that catalyzes a key step in glycolysis, namely the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate by ATP. Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway.
 


 

Images

 

Immunohistochemistry analysis of paraffin-embedded human liver cancer using PFKL (GB111136) at dilution of 1: 1600

   

Immunohistochemistry analysis of paraffin-embedded human prostate using PFKL (GB111136) at dilution of 1: 1600

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.

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