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Anti -Lipocalin-2 / NGAL Rabbit pAb

Cat. No. GB111134

Brand:Servicebio

Price:230

Specification: 100μl

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Product Information

 

Description

NGAL rabbit polyclonal

Protein full name

Neutrophil gelatinase-associated lipocalin

Synonyms

NGAL, Lipocalin-2, Oncogene 24p3, Siderocalin, p25

Immunogen

Recombinant protein corresponding to Human NGAL

Isotype IgG
Purity Affinity purification
Subcellular location

Secreted

Uniprot ID

P80188

 


 

Applications

 

Applications

IHC

IF

Species

Human

Human

Dilution

1: 500-1: 1000

1: 500-1: 1000

Positive tissue

lung, lung cancer, liver cancer

colon

 


 

Background

 

Lipocalin 2 is a member of the lipocalin family, It involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.

 


 

Images

 

Immunohistochemistry analysis of paraffin-embedded human lung using NGAL (GB111134) at dilution of 1: 1000

   

Immunohistochemistry analysis of paraffin-embedded human lung cancer using NGAL (GB111134) at dilution of 1: 1000

   

Immunohistochemistry analysis of paraffin-embedded human liver cancer using NGAL (GB111134) at dilution of 1: 1000

   

Immunofluorescent analysis of paraffin-embedded human colon using NGAL (GB111134) at dilution of 1:1000

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.

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