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Anti -GFAP Mouse mAb

Cat. No. GB14089

Brand:Servicebio

Price:230.00

Specification: 50μl

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Product Information:

 

Gene Name:GFAP

Protein Name:Glial fibrillary acidic protein (GFAP)

Human Gene Id:2670

Human Swiss Prot No:P14136

Immunogen:Synthesized peptide derived from human Glial Fibrillary Acidic Protein (GFAP)

Specificity:This antibody detects endogenous levels of human Glial Fibrillary Acidic Protein (GFAP)

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source:Mouse/IgG1, Kappa

Dilution:IHC-p 1:100-200

Purification:The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Concentration:1 mg/ml

Storage Stability:-20°C/1 year

Background: glial fibrillary acidic protein(GFAP) Homo sapiens This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008],

Function: alternative products:Isoforms differ in the C-terminal region which is encoded by alternative exons, disease: Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course, function: GFAP, a class-III intermediate filament.

Subcellular Location: Cytoplasmic.

Expression: Blood, Brain, Fetal brain, Fetal brain cortex, Kidney.

 

Precautions:

 

1. Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.

2. This product is intended for research only.

 

Images:

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Immunohistochemical analysis of paraffin-embedded Brain. 1, Antibody was diluted at 1:200(4°,overnight). 2, Tris-EDTA, pH8.0 was used for antigen retrieval. 

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Immunohistochemical analysis of paraffin-embedded Glioma. 1, Antibody was diluted at 1:200(4°,overnight). 2, Tris-EDTA, pH8.0 was used for antigen retrieval. 

 

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