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Anti -CD81 Rabbit pAb

Cat. No. GB111073

Brand:Servicebio

Price:230

Specification: 100μl

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Product Information

 

Description CD81 rabbit polyclonal
Protein full name CD81 antigen
Synonyms 26 kDa cell surface protein TAPA-1, Target of the antiproliferative antibody 1, CD81, Tapa1
Immunogen KLH conjugated Synthetic peptide
corresponding to Mouse CD81
Isotype IgG
Purity Affinity purification
Predicted MW. 26 kDa
Observed MW. 30 kDa
Uniprot ID P60033, P35762, Q62745

 


 

Applications

 

Applications Species Dilution Positive Tissue
WB Human, Mouse, Rat 1: 500-1: 1000 muscle

 


 

Background

 

CD81 (TAPA-1, target of anti-proliferative antibody-1) is a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T cells. In muscles, CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus. CD81 is a cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.CD81 appears to promote muscle cell fusion and support myotube maintenance. Antibodies to CD81 have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas. CD81 is also localized in the tumor-suppressor gene region and is a candidate gene for malignancies.
 


 

Images

 

Western blot analysis of CD81 (GB111073) at dilution of 1: 1000

Lane 1: LO2 cell lysate
Lane 2: Mouse muscle tissue lysate
Lane 3: Rat muscle tissue lysate

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.