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Anti -CD81 Rabbit pAb

Cat. No. GB111073

Brand:Servicebio

Price:230

Specification: 100μl

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Product Information

 

Description

CD81 rabbit polyclonal

Protein full name

CD81 antigen

Synonyms

26 kDa cell surface protein TAPA-1, Target of the antiproliferative antibody 1, CD81, Tapa1

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse CD81

Isotype IgG
Purity Affinity purification

Predicted MW.

26 kDa

Observed MW.

26-30 kDa

Uniprot ID

P60033, P35762, Q62745

 


 

Applications

 

Applications

WB

Species

Human, Mouse, Rat

Dilution

1: 500-1: 1000

Positive tissue

muscle

 


 

Background

 

CD81 (TAPA-1, target of anti-proliferative antibody-1) is a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T cells. In muscles, CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus. CD81 is a cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.CD81 appears to promote muscle cell fusion and support myotube maintenance. Antibodies to CD81 have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas. CD81 is also localized in the tumor-suppressor gene region and is a candidate gene for malignancies.
 


 

Images

 

Western blot analysis of CD81 (GB111073) at dilution of 1: 1000

Lane 1: LO2 cell lysate
Lane 2: Mouse muscle tissue lysate
Lane 3: Rat muscle tissue lysate

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

 


 

NOTE: This product is intended for research only.