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Anti -SRC3 Rabbit pAb

Cat. No. GB111066

Brand:Servicebio

Price:230

Specification: 100μl

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Product Information

 

Description

SRC3 rabbit polyclonal

Protein full name

Nuclear receptor coactivator 3

Synonyms

NCoA-3, AIB-1, CBP-interacting protein, pCIP, RAC-3, SRC-3, ACTR, TRAM-1, Ncoa3, Aib1, Pcip, Rac3, Tram1

Immunogen

Recombinant protein corresponding to Mouse SRC3

Isotype IgG
Purity Affinity purification
Subcellular location

Cytoplasm, Nucleus

Uniprot ID

Q9Y6Q9, O09000, Q9EPU2

 


 

Applications

 

Applications

IHC

IF

Species

Human, Mouse, Rat

Human, Mouse, Rat

Dilution

1: 1000-1: 2000

1: 500-1: 1000

Positive tissue

breast cancer, ovary, brain

breast cancer, ovary, brain

 


 

Background

 

The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. SRC3 is an oncogene that is reported to be amplified and/or overexpressed in breast and gastric cancer and stimulates AKT signaling and cell growth and tumorigenesis.
 


 

Images

 

Immunohistochemistry analysis of paraffin-embedded human breast cancer using SRC3 (GB111066) at dilution of 1: 2000

   

Immunohistochemistry analysis of paraffin-embedded mouse ovary using SRC3 (GB111066) at dilution of 1: 2000

   

Immunohistochemistry analysis of paraffin-embedded mouse brain using SRC3 (GB111066) at dilution of 1: 2000

   

Immunohistochemistry analysis of paraffin-embedded rat brain using SRC3 (GB111066) at dilution of 1: 2000

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.