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Anti -KAT5 / Tip60 Rabbit pAb

Cat. No. GB111065

Brand:Servicebio

Price:230

Specification: 100μl

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Product Information

 

Description

Tip60 rabbit polyclonal

Protein full name

Histone acetyltransferase KAT5

Synonyms

60 kDa Tat-interactive protein, Tip60, Histone acetyltransferase HTATIP, Lysine acetyltransferase 5, Kat5, Htatip, Tip60

Immunogen

Recombinant protein corresponding to Mouse Tip60

Isotype IgG
Purity Affinity purification
Subcellular location

Cytoplasm, Nucleus

Uniprot ID

Q92993, Q8CHK4, Q99MK2

 


 

Applications

 

Applications

IHC

IF

Species

Human, Mouse, Rat

Human, Mouse, Rat

Dilution

1: 1000-1: 2000

1: 500-1: 1000

Positive tissue

lung cancer, breast cancer, brain, heart

lung cancer, breast cancer, brain, heart

 


 

Background

 

Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.

 


 

Images

 

Immunohistochemistry analysis of paraffin-embedded human lung cancer using Tip60 (GB111065) at dilution of 1: 2000

   

Immunohistochemistry analysis of paraffin-embedded human breast cancer tumor using Tip60 (GB111065) at dilution of 1: 2000

   

Immunohistochemistry analysis of paraffin-embedded mouse brain using Tip60 (GB111065) at dilution of 1: 2000

   

Immunohistochemistry analysis of paraffin-embedded rat brain using
Tip60 (GB111065) at dilution of 1: 2000

   

Immunohistochemistry analysis of paraffin-embedded rat heart using
Tip60 (GB111065) at dilution of 1: 2000

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.