Gene Name：CALD1 CAD CDM
Protein Name：Caldesmon (CDM)
Human Gene Id：800
Human Swiss Prot No：Q05682
Immunogen：Synthesized peptide derived from human Caldesmon
Specificity：This antibody detects endogenous levels of human Caldesmon
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification：The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Storage Stability：-20°C/1 year
Background: caldesmon 1(CALD1) Homo sapiens This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008],
Function: domain: The N-terminal part seems to be a myosin/calmodulin-binding domain, and the C-terminal a tropomyosin/actin/calmodulin-binding domain. These two domains are separated by a central helical region in the smooth-muscle form.,function:Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping,PTM:In non-muscle cells, phosphorylation by CDC2 during mit
Subcellular Location: Cytoplasmic
Expression: Amygdala, Aorta, Epithelium, Human rectum tumor, Liver, Lung, Lung fibroblast, Pancreas, Skin.
1. Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
2. This product is intended for research only.