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Anti -Caldesmon Mouse mAb

Cat. No. GB14015

Brand:Servicebio

Price:230.00

Specification: 50μl

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Product Information:

 

Gene Name:CALD1 CAD CDM

Protein Name:Caldesmon (CDM)

Human Gene Id:800

Human Swiss Prot No:Q05682

Immunogen:Synthesized peptide derived from human Caldesmon

Specificity:This antibody detects endogenous levels of human Caldesmon

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source:Mouse/IgG2b, Kappa

Dilution:IHC-p 1:200

Purification:The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Concentration:1 mg/ml

Storage Stability:-20°C/1 year

Background: caldesmon 1(CALD1) Homo sapiens This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008],

Function: domain: The N-terminal part seems to be a myosin/calmodulin-binding domain, and the C-terminal a tropomyosin/actin/calmodulin-binding domain. These two domains are separated by a central helical region in the smooth-muscle form.,function:Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping,PTM:In non-muscle cells, phosphorylation by CDC2 during mit

Subcellular Location: Cytoplasmic

Expression: Amygdala, Aorta, Epithelium, Human rectum tumor, Liver, Lung, Lung fibroblast, Pancreas, Skin.

 

Precautions:

 

1. Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.

2. This product is intended for research only.

 

Images:

 

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Immunohistochemical analysis of paraffin-embedded Fibroid. 1, Antibody was diluted at 1:200(4°,overnight). 2, Tris-EDTA, pH8.0 was used for antigen retrieval. 

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Immunohistochemical analysis of paraffin-embedded Liomyoma. 1, Antibody was diluted at 1:200(4°,overnight). 2, Tris-EDTA, pH8.0 was used for antigen retrieval. 

 

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