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Anti -Src Rabbit pAb

Cat. No. GB111035

Brand:Servicebio

Price:230.00

Specification: 100μl

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Product Information

 

Description

Src rabbit polyclonal

Protein full name

Neuronal proto-oncogene tyrosine-protein kinase Src

Synonyms

Proto-oncogene c-Src, pp60c-src, p60-Src, Src

Immunogen

Recombinant protein corresponding to Mouse Src

Isotype IgG
Purity Affinity purification
Subcellular location

Cell membranem, Cytoplasm, Nucleus

Uniprot ID

P12931P05480Q9WUD9

 


 

Applications

 

Applications

IHC

IF

Species

Human, Mouse, Rat

Human, Mouse, Rat

Dilution

1: 1000-1: 2000

1: 500-1: 1000

Positive tissue

breast cancer, brain, small intestine

breast cancer, brain, small intestine

 


 

Background

 

SRC, also named as SRC1 and p60-Src, belongs to the protein kinase superfamily, Tyr protein kinase family and SRC subfamily. It is a non-receptor protein tyrosine kinase that plays pivotal roles in numerous cellular processes such as proliferation, migration, and transformation. In concert with PTK2B, SRC plays an important role in osteoclastic bone resorption. It promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.

 


 

Images

 

Immunohistochemistry analysis of paraffin-embedded human breast cancer  using Src (GB111035) at dilution of 1: 2000

   

Immunohistochemistry analysis of paraffin-embedded mouse brain using Src (GB111035) at dilution of 1: 2000

   

Immunohistochemistry analysis of paraffin-embedded mouse small intestine using Src (GB111035) at dilution of 1: 2000

   

Immunohistochemistry analysis of paraffin-embedded rat brain using Src (GB111035) at dilution of 1: 2000

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

 


 

NOTE: This product is intended for research only.