Chinese | English  
Servicebio

TEL

+86 (0) 27 5111 3188

Polyclonals

  1. Home
  2. Products
  3. Primary antibodies
  4. Polyclonals
  5. Content

Anti -SQSTM1/p62 Rabbit pAb

Cat. No. GB11239-1

Brand:Servicebio

Price:230.00

Specification: 100μl

Download Attachment Files
Attachment Download Address: ×
/e/DownSys/DownSoft/?classid=19&id=1464&pathid=0

Product Information

 

 

Description

P62 rabbit polyclonal

Protein full name

Sequestosome-1

Synonyms

SQSTM1, A170, OSIL, PDB3, ZIP3, p60, p62, p62B, FTDALS3, Sequestosome 1, NADGP, DMRV

Immunogen

Recombinant protein corresponding to Mouse P62

Isotype IgG
Purity Affinity purification

Predicted MW.

48KDa

Observed MW.

62KDa

Subcellular location Late endosome, Nucleus, PML body, Lysosome, Endoplasmic reticulum, Cytosol, autophagosome, sarcome
Uniprot ID

Q13501, O08623, Q64337

 


 

Applications

 

 

Applications

WB

   
Species

Human, Mouse, Rat

   
Dilution

1:500-1:1500

   
Positive tissue

MCF-7, 293Tlivermuscle

   

 


 

Background

 

 

Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD.

   


 

Images

 

 

Western blot analysis of P62 (GB11239-1) at dilution of 1:1000.

Lane 1: MCF-7 cell lysate

Lane 2: 293T cell lysate

Lane 3: A549 cell lysate

Lane 4: Mouse muscle tissue lysate

Lane 5: Mouse liver tissue lysate

Lane 6: Mouse heart tissue lysate

Lane 7: Rat muscle tissue lysate

Lane 8: Rat liver tissue lysate

 


 

Storage

 

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

 


 

NOTE: This product is intended for research only.