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Anti -SQSTM1/P62 Rabbit pAb

Cat. No. GB11239

Brand:Servicebio

Price:230.00

Specification: 100μlThis product is temporarily out of stock.

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Product Information

 

 

Description

SQSTM1 rabbit polyclonal

Protein full name

Sequestosome-1

Synonyms

SQSTM1, A170, OSIL, PDB3, ZIP3, p60, p62, p62B, FTDALS3, Sequestosome 1, NADGP, DMRV

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse SQSTM1 

Isotype IgG
Purity Affinity purification
Subcellular location

CytoplasmLate endosomeLysosomeCytoplasmic vesicleNucleusEndoplasmic reticulum

Uniprot ID

Q13501Q64337

 


 

Applications

 

 

Applications

IHC, IF

   
Species

Human

   
Dilution

1:500-1:1000

   
Positive tissue

gallbladder

   

 


 

Background

 

 

Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation . May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels. Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport.

    

 


 

Images

 

 

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Immunohistochemistry analysis of paraffin-embedded human gallbladder using SQSTM1 (GB11239) at dilution of 1:500

 

   

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Immunohistochemistry analysis of paraffin-embedded human gallbladder using SQSTM1 (GB11239) at dilution of 1:1000

 

 


 

Storage

 

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.