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Anti -Fas Ligand Rabbit pAb

Cat. No. GB11090

Brand:Servicebio

Price:230.00

Specification: 100μl

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Product Information

 

 

Description

Fas Ligand rabbit polyclonal

Protein full name

Tumor necrosis factor ligand superfamily member 6

Synonyms

FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6, TNLG1A, Fas ligand

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse FASL

Isotype IgG
Purity Affinity purification
Predicted MW.

31KDa

Observed MW.

31KDa

Uniprot ID

P48023,P41047,P36940

 


 

Applications

 

 

Applications

WB

   
Species

Human, Mouse, Rat

   
Dilution

1:1000

   
Positive tissue

LNCap, breast cancer, liver, spleen, brain

   

 


 

Background

 

Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. Tumor necrosis factor ligand superfamily member 6, soluble form: Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process.

     


 

Images

 

 

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Western blot analysis of FASL(GB11090) at dilution of 1:1000.

Lane 1: LNCaP cell tissue lysate

Lane 2: Human breast cancer tissue lysate

Lane 3: Mouse liver tissue lysate

Lane 4: Mouse spleen tissue lysate

Lane 5: Mouse brain tissue lysate

Lane 6: Rat liver tissue lysate

Lane 7: Rat spleen tissue lysate

 


 

Storage

 

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

 


 

NOTE: This product is intended for research only.