Chinese | English  
Servicebio

TEL

+86 (0) 27 5111 3188

Polyclonals

  1. Home
  2. Products
  3. Primary antibodies
  4. Polyclonals
  5. Content

Anti -EGFR Rabbit pAb

Cat. No. GB11084-1

Brand:Servicebio

Price:230.00

Specification: 100μl

Download Attachment Files
Attachment Download Address: ×
/e/DownSys/DownSoft/?classid=19&id=1366&pathid=0

Product Information

 

 

Description EGFR rabbit polyclonal
Protein full name Epidermal growth factor receptor

Synonyms

EGFR, ERBB, ERBB1, HER1, NISBD2, PIG61, mENA, epidermal growth factor receptor

Immunogen KLH conjugated Synthetic peptide corresponding to Mouse EGFR
Isotype IgG
Purity Affinity purification
Predicted MW. 134KDa
Observed MW. 175KDa
Uniprot ID

P00533,Q01279

 


 

Applications

 

 

Applications WB    
Species Human    
Dilution 1:600-1:1000    
Positive tissue

HepG2, A549, A431, Hacat, Hct116

   

 


 

Background

 

 

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules.

        


 

Images

 

 

blob.png

Western blot analysis of EGFR (GB11084-1) at dilution of 1:1000.

Lane 1: HepG2 cell lysate

Lane 2: A549 cell lysate

Lane 3: A431 cell lysate

Lane 4: Hacat cell lysate

Lane 5: Hct116 cell lysate

 


 

Storage

 

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.