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Anti -Cytochrome C Rabbit pAb

Cat. No. GB11080

Brand:Servicebio

Price:230.00

Specification: 100μl

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Product Information

 

 

Description Cytochrome c rabbit polyclonal
Protein full name Cytochrome c

Synonyms

CYCS, CYC, HCS, THC4, cytochrome c, somatic, Cytochrome c, cyt c
Immunogen KLH conjugated Synthetic peptide corresponding to Mouse Cytochrome c
Isotype IgG
Purity Affinity purification
Predicted MW.

12KDa

Observed MW.

12KDa

Subcellular location Mitochondrion intermembrane space
Uniprot ID P99999P62898P62897

 


 

Applications

 

 

Applications

WB

IHC

IF

Species

Human, Mouse, Rat

Human, Mouse, Rat

Human, Mouse, Rat

Dilution

1:1000

1:500-1:2000

1:200-1:1000

Positive tissue

brain, lung, HepG2

lung cancer, kidney

kidney, lung

 


 

Background

 

 

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase.Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

   


 

Images

 

 

blob.png

Western blot analysis of Cytochrome c (GB11080) at dilution of 1:1000.

Lane 1: Hela cell lysate

Lane 2: HepG2 cell lysate

Lane 3: Mouse lung tissue lysate

Lane 4: Mouse brain tissue lysate

Lane 5: Rat brain tissue lysate

   

blob.png

Immunohistochemistry analysis of paraffin-embedded human lung cancer using Cytochrome c (GB11080) at dilution of 1:2000
   

blob.png

Immunofluorescence analysis of paraffin-embedded mouse kidney using Cytochrome c (GB11080) at dilution of 1:1000

 


 

Storage

 

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

 


 

NOTE: This product is intended for research only.