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Anti -Cyclin D1 Rabbit pAb

Cat. No. GB11079

Brand:Servicebio

Price:230.00

Specification: 100μlThis product is temporarily out of stock.

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Product Information

 

Description Cyclin D1 rabbit polyclonal
Protein full name G1/S-specific cyclin-D1
Synonyms CCND1, BCL1, D11S287E, PRAD1, U21B31, cyclin D1
Immunogen KLH conjugated Synthetic peptide
corresponding to Mouse Cyclin D1
Isotype IgG
Purity Affinity purification
Predicted MW. 33KDa
Observed MW. 34KDa
Uniprot ID P25322

 


 

Applications

 

applications species dilution Positive tissue
WB Human,Mouse,Rat 1:500-1:1000 HACAT, HepG2, lung, 
kidney, skin

 


 

Background

 

 

The protein belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDKs (Cyclin-dependent kinase). Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

 


 

Images

 

 

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Western blot analysis of Cyclin D1 (GB11079) at dilution of 1:1000.

Lane 1:HACAT cell lysate

Lane 2:HepG2 cell lysate

Lane 3:A431 cell lysate

Lane 4:Mouse lung tissue lysate

Lane 5: Mouse kidney tissue lysate

Lane 6:Mouse skin tissue lysate

Lane 7:Rat lung tissue lysate

Lane 8:Rat kidney tissue lysate

Lane 9:Rat skin tissue lysate

 


 

Storage

 

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.