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Anti -Caspase-3 Rabbit pAb

Cat. No. GB11009-1

Brand:Servicebio

Price:230.00

Specification: 100μlThis product is temporarily out of stock.

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Product Information

 

 

Description

Caspase-3 rabbit polyclonal

Protein full name Caspase-3
Synonyms CASP3, CPP32, CPP32B, SCA-1, caspase 3, caspase-3, caspase3 
Immunogen Recombinant protein corresponding to Mouse Caspase3
Isotype IgG
Purity Affinity purification
Subcellular location Cytoplasm
Uniprot ID

P42574,P70677,P55213

 


 

Applications

 

 

Applications IHC, IF
Species Human, Rat
Dilution 1:100-1:200
Positive tissue Liver, stomach

 


 

Background

 

 

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.

 


 

Images

 

 

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Immunohistochemistry analysis of paraffin-embedded human Uterine fibroids using Caspase3 (GB11009-1) at dilution of 1:200

 

 

   
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Immunohistochemistry analysis of paraffin-embedded human Gastric cancer using Caspase3 (GB11009-1) at dilution of 1:200

 

   
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Immunohistochemistry analysis of paraffin-embedded human liver using Caspase3 (GB11009-1) at dilution of 1:200

 

 


 

Storage

 

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.