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Anti -Phospholipase C gamma 1 / PLC-gamma-1 Rabbit pAb

Cat. No. GB11569

Brand:Servicebio

Price:230.00

Specification: 100μl

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Product Information

 

 

Description PLCγ1 rabbit polyclonal
Protein full name 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase gamma-1

Synonyms

PLCG1, NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1, phospholipase C gamma 1
Immunogen Recombinant protein corresponding to Mouse PLCγ1
Isotype IgG
Purity Affinity purification

Predicted MW.

149 kDa

Observed MW.

160 kDa
Uniprot ID

P19174

 


 

Applications

 

 

Applications

WB

Species Human
Dilution 1:500-1:1000
Positive tissue

Jurkat, MCF7, Hela

 


 

Background

 

 

Phospholipase C, gamma 1, also known as PLCG1, is a protein that in humans is encoded by the PLCG1 gene. This protein catalyzes the formation of inositol 1, 4, 5-trisphosphate and diacylglycerol from phosphatidylinositol 4, 5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1(acidic fibroblast growth factor) -activated tyrosine kinase.

        


 

Images

 

 

wb-10.jpg  

Western blot analysis of PLCγ1(GB11569) at dilution of 1:800

Lane 1: Jurkat cell lysate

Lane 2: MCF7 cell lysate

Lane 3: Hela cell lysate

 


 

Storage

 

 

Storage

Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.

Storage Buffer

PBS with 0.02%sodium azide, 100 μg/ml BSA and 50% glycerol.

 


 

NOTE:This product is intended for research only.