|Positive tissue||lung, kidney|
Integrin beta-1 (ITGB1), also known as CD29, is a cell surface receptor. This integrin associates with integrins alpha 1 and 2 to form integrin complexes which function as collagen receptors. It also forms dimers with integrin alpha 3 to form integrin receptors for netrin 1 and reelin. Integrin beta 1 is expressed as at least four different isoforms. In cardiac muscle and skeletal muscle, the integrin beta-1D isoform is specifically expressed, and localizes to costameres, where it aids in the lateral force transmission from the Z-discs to the extracellular matrix. Abnormal levels of integrin beta-1D have been found in limb girdle muscular dystrophy and polyneuropathy.
Western blot analysis of Integrin beta 1 (GB11537) at dilution of 1:1000.
Lane 1: Mouse lung tissue lysate
Lane 2: Mouse kidney tissue lysate
Lane 3: Rat lung tissue lysate
Lane 4: Rat kidney tissue lysate