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Anti -active Caspase-3 Rabbit pAb

Cat. No. GB11532

Brand:Servicebio

Price:230.00

Specification: 100μl

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Product Information

 

 

Description

active Caspase-3 rabbit polyclonal

Protein full name

Caspase-3

Synonyms

CASP3, CPP32, CPP32B, SCA-1, caspase 3, caspase-3, caspase3

Immunogen KLH conjugated Synthetic peptide corresponding to Mouse caspase3 
Isotype IgG
Purity Affinity purification
Subcellular location

Cytoplasm

Uniprot ID P70677P42574P55213

 


 

Applications

 

 

Applications

IHC, IF

Species

Human, Mouse, Rat

Dilution

1:500-1:1000

Positive tissue

Mouse tumor, A549 mice tumor, MCF-7 mice tumor

 


 

Background

 

 

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.

      


 

Images

 

 

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Immunohistochemistry analysis of paraffin-embedded A549 in mice tumor using Cleaved-Caspase3 (GB11532) at dilution of 1:1000,untread (left),treated with the control peptide antigen (right) .

   
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Immunohistochemistry analysis of paraffin-embedded MCF-7 in mice tumor using Cleaved-Caspase3 (GB11532) at dilution of 1:1000,untread (left),treated with the control peptide antigen (right) .

 

   
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Immunohistochemistry analysis of paraffin-embedded mouse tumor using Cleaved-Caspase3 (GB11532) at dilution of 1:1000,untread (left),treated with the control peptide antigen (right) .

 

 


 

Storage

 

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.