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Anti -SQSTM1 / p62 Rabbit pAb

Cat. No. GB11531

Brand:Servicebio

Price:230.00

Specification: 100μl

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Product Information

 

 

Description

SQSTM1 / p62 rabbit polyclonal

Protein full name Sequestosome-1

Synonyms

SQSTM1, A170, OSIL, PDB3, ZIP3, p60, p62, p62B, FTDALS3, Sequestosome 1, NADGP, DMRV
Immunogen KLH conjugated Synthetic peptide corresponding to Human SQSTM1
Isotype IgG
Purity Affinity purification

Predicted MW.

48 kDa

Observed MW.

62 kDa
Uniprot ID

Q13501, Q64337, O08623

 


 

Applications

 

 

Applications

WB

Species

Human, Mouse, Rat

Dilution 1:500-1:1000
Positive tissue Hela, HIN3T3, HepG2, MCF7

 


 

Background

 

 

The product of SQSTM1 gene, Sequestosome-1, also kown as ubiquitin-binding protein p62, is an autophagosome cargo protein that targets other proteins that bind to it for selective autophagy. By interacting with GATA4 and targeting it for degradation, it can inhibit GATA-4 associated senescence and senescence-associated secretory phenotype. 

    


 

Images

 

 

image.png  

Western blot analysis of SQSTM1 / p62 (GB11531)  at dilution of 1:1000 (upper) or β-actin (lower).

Lane 1: Hela (untreated) cell lysate

Lane 2: Hela (treated with Chloroquine, 50 μM, overnight ) cell lysate

Lane 3: NIH3T3 (untreated) cell lysate

Lane 4: NIH3T3 (treated with Chloroquine, 50 μM, overnight ) cell lysate

Lane 5: HepG2 cell lysate

Lane 6: MCF7 cell lysate

Lane 7: A549 cell lysate

Lane 8: L929 cell lysate

Lane 9: PC12 cell lysate

 

 


 

Storage

 

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.