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Anti-SIRT1 Rabbit pAb

Cat. No. GB11512

Brand:Servicebio

Price:230.00

Specification: 50/100 μl

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Product Information

 

Description SIRT1 rabbit polyclonal
Protein full name NAD-dependent protein deacetylase sirtuin-1
Synonyms SIRT1,SIR2L1,SIR2,hSIR2,SIR2alpha,
Sirtuin 1
Immunogen Recombinant protein corresponding to Mouse SIRT1
Isotype IgG
Purity Affinity purification
Subcellular location Nucleus,Cytoplasm
Uniprot ID Q923E4

 


 

Applications

 

applications species dilution Positive tissue
IHC Mouse 1:300-1:700 Testis,brain,heart
IF Mouse, Rat 1:1000-1:2000 ovary, spleen, small intestine, testis

 


 

Background

 

Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by theSIRT1 gene.Sirtuin 1 is downregulated in cells that have high insulin resistance and inducing its expression increases insulin sensitivity, suggesting the molecule is associated with improving insulin sensitivity. Furthermore, SIRT1 was shown to de-acetylate and affect the activity of both members of the PGC1-alpha/ERR-alpha complex, which are essential metabolic regulatory transcription factors.

    


 

Images

 

 

Immunohistochemistry analysis of paraffin-embedded mouse testis using SIRT1 (GB11512) at dilution of 1:500.

 

Immunohistochemistry analysis of paraffin-embedded mouse brain using SIRT1 (GB11512) at dilution of 1:500.

Immunohistochemistry analysis of paraffin-embedded mouse heart using SIRT1 (GB11512) at dilution of 1:500.

Immunohistochemistry analysis of paraffin-embedded mouse ovary using SIRT1 (GB11512) at dilution of 1:2000.

Immunohistochemistry analysis of paraffin-embedded mouse spleen using SIRT1 (GB11512) at dilution of 1:1000.

Immunohistochemistry analysis of paraffin-embedded mouse small intestinet using SIRT1 (GB11512) at dilution of 1:1000.
 
Immunohistochemistry analysis of paraffin-embedded rat testis using SIRT1 (GB11512) at dilution of 1:1000.

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

 


 

NOTE: This product is intended for research only.