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Anti-JMJD6 Rabbit pAb

Cat. No. GB11341

Brand:Servicebio

Price:230.00

Specification: 100μl

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Product Information

 

 

Description JMJD6 rabbit polyclonal
Protein full name Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Synonyms

JMJD6, PSR, PTDSR, PTDSR1, arginine demethylase and lysine hydroxylase
Immunogen KLH conjugated Synthetic peptide corresponding to Mouse JMJD6 
Isotype IgG
Purity Affinity purification
Subcellular location

Nucleus

Uniprot ID Q9ERI5

 


 

Applications

 

 

Applications

IHC, IF

Species

Human, Mouse, Rat

Dilution

1:1000-1:3000

Positive tissue

Colon, spleen, kidney, heart, stomach cancer

 


 

Background

 

 

Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses (By similarity).

   


 

Images

 

 

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Immunohistochemistry analysis of paraffin-embedded human colon cancer using JMJD6 (GB11341) at dilution of 1:2000.

 

   
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Immunohistochemistry analysis of paraffin-embedded human stomach cancer using JMJD6 (GB11341) at dilution of 1:2000.

 

   
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Immunohistochemistry analysis of paraffin-embedded mouse colon using JMJD6 (GB11341) at dilution of 1:2000.

 

   
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Immunohistochemistry analysis of paraffin-embedded mouse kidney using JMJD6 (GB11341) at dilution of 1:2000.

 

   
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Immunohistochemistry analysis of paraffin-embedded rat heart using JMJD6 (GB11341) at dilution of 1:2000.

 

   
image.png

Immunohistochemistry analysis of paraffin-embedded rat spleen using JMJD6 (GB11341) at dilution of 1:2000.

 

 


 

Storage

 

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.

 

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