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Anti -Myelin Basic Protein Rabbit pAb

Cat. No. GB11226

Brand:Servicebio

Price:230.00

Specification: 100μl

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Product Information

 

Description Myelin Basic Protein rabbit polyclonal
Protein full name Myelin Basic Protein
Synonyms MBP, entrez:4155, myelin basic protein
Immunogen KLH conjugated Synthetic peptide
corresponding to Mouse Myelin Basic Protein
Isotype IgG
Purity Affinity purification
Predicted MW. 27 kDa
Observed MW. 17/20 kDa
Subcellular location Myelin membrane, 
Cytoplasmic side of myelin
Uniprot ID P04370, P02688

 


 

Applications

 

Applications Species Dilution Positive Tissue
WB Mouse, Rat 1: 500-1: 1000 brain
IHC, IF Mouse, Rat 1: 300-1: 600 brain

 


 

Background

 

 

The classic group of MBP isoforms (isoform 4-isoform 13) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined to optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function.

     


 

Images

 

 

blob.png

Western blot analysis of Myelin Basic Protein (GB11226) at dilution of 1:1000.

Lane 1:Mouse brain tissue lysate

Lane 2:Mouse hippocampus tissue lysate

Lane 3:Mouse cerebellum tissue lysate

Lane 4:Rat brain tissue lysate

Lane 5:Rat hippocampus tissue lysate

Lane 6:Rat cerebellum tissue lysate

   

blob.png

Immunohistochemistry analysis of paraffin-embedded mouse brain using Myelin Basic Protein (GB11226) at dilution of 1:600

   

blob.png

Immunohistochemistry analysis of paraffin-embedded rat brain using Myelin Basic Protein (GB11226) at dilution of 1:600

 


 

Storage

 

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.