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Anti - Tyrosine Hydroxylase Rabbit pAb

Cat. No. GB11181

Brand:Servicebio

Price:230.00

Specification: 100μl

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Product Information

 

 

Description

Tyrosine Hydroxylase rabbit polyclonal

Protein full name

Tyrosine 3-monooxygenase

Synonyms

TH, Th, DYT14, DYT5b, TYH, tyrosine hydroxylase, Tyrosine hydroxylase

Immunogen

Recombinant protein corresponding to Mouse Tyrosine Hydroxylase

Isotype IgG
Purity Affinity purification
Predicted MW.

62KDa

Observed MW.

62KDa

Subcellular location

Cytoplasm, Axon

Uniprot ID

P24529P04177

 


 

Applications

 

 

Applications

WB

IHC, IF

 
Species

Mouse, Rat

Mouse, Rat

 
Dilution

1:1000

1:500-1:1000

 
Positive tissue

U251, N2A, C6

Striatum, brain

 

 


 

Background

 

Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA). It does so using molecular oxygen(O2), as well as iron (Fe2+) and tetrahydrobiopterin as cofactors. L-DOPA is a precursor for dopamine, which, in turn, is a precursor for the important neurotransmitters norepinephrine (noradrenaline) and epinephrine(adrenaline). Tyrosine hydroxylase catalyzes the rate limiting step in this synthesis of catecholamines. In humans, tyrosine hydroxylase is encoded by the TH gene,and the enzyme is present in the central nervous system (CNS), peripheral sympathetic neurons and the adrenal medulla.Tyrosine hydroxylase, phenylalanine hydroxylase  and tryptophan hydroxylase together make up the family of aromatic amino acid hydroxylases(AAAHs).


 

Images

 

 

blob.png

Western blot analysis of Tyrosine Hydroxylase (GB11181) at dilution of 1:1000

Lane 1: U251 cell lysate

Lane 2: N2A cell lysate

Lane 3: C6 cell lysate

   

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Immunohistochemistry analysis of paraffin-embedded rat brain striatum using TH(GB11181) at dilution of 1:1000

 

   

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Immunofluorescence analysis of paraffin-embedded mouse brain using TH(GB11181) at dilution of 1:500

 

 


 

Storage

 

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

 


 

NOTE: This product is intended for research only.