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Anti -E-Cadherin Mouse mAb

Cat. No. GB14076

Brand:Servicebio

Price:230.00

Specification: 50μlThis product is temporarily out of stock.

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Product Information

 

Description E-cadherin mouse polyclonal
Protein full name Epithelial cadherin
Synonyms CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO, cadherin 1, BCDS1
Immunogen Synthesized peptide derived from human E-Cadherin
Isotype IgG
Purity Affinity purification
Subcellular location Cell membrane
Uniprot ID P12830

 


 

Applications

 

Applications Species Dilution Positive Tissue
IHC、IF Human 1: 200-1: 500 brain, epidermal carcinoma, hippocampus, liver, pancreas, placenta

 


 

Background
 

cadherin 1(CDH1) Homo sapiens This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.

 


 

Images

 

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

 


 

NOTE: This product is intended for research only.

 

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