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GB112533 Anti -GPCR GPR120 Ffar4 O3far1 Rabbit Polyclonal Antibody for IHC IF

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse GPR120
Isotype: IgG
Purity: Affinity purification
ul:
  • GB112533
  • Servicebio

Description

Product Information


Description

GPCR GPR120 rabbit polyclonal

Protein full name

Free fatty acid receptor 4

Synonyms

G-protein coupled receptor 120, G-protein coupled receptor GT01, Omega-3 fatty acid receptor 1, Gpr120, O3far1, Ffar4

Immunogen

KLH conjugated Synthetic peptide

corresponding to Mouse GPR120

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cell membrane, EndosomeLysosome

Uniprot ID

Q7TMA4, Q2AC31




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Mouse, Rat

1: 1000-1: 2000

pancreas, white fat, pituitary gland




Background


GPR120, a member of the rhodopsin family of G protein-coupled receptors (GPCRs), is a 377 amino acid protein which is expressed in the intestine. GPR120 is a receptor for unsaturated long-chain FFAs (free fatty acids). FFAs act as signaling molecules and are an important energy source. They also employ various physiological responses through their GPCRs. One such response occurs when dietary FFAs stimulate GPR120. This stimulation promotes the secretion of glucagon-like peptide 1 (GLP-1) in vivo and in vitro. GLP-1 belongs to the class of molecules known as the incretins, which are associated with insulin secreted from the pancreas as a result of food intake. GLP-1 also inhibits glucagon and gastric acid secretion and gastric emptying. Consequently, the role of GPR120 in the secretion of GLP-1 is critical in the treatment of diabetes.




Images


Immunohistochemistry analysis of paraffin-embedded mouse pancreas using 

GPR120 (GB112533) at dilution of 1: 2000

Immunohistochemistry analysis of paraffin-embedded mouse white fat using 

GPR120 (GB112533) at dilution of 1: 2000

Immunohistochemistry analysis of paraffin-embedded rat white fat using 

GPR120 (GB112533) at dilution of 1: 2000

Immunohistochemistry analysis of paraffin-embedded mouse pituitary gland using GPR120 (GB112533) at dilution of 1: 2000




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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