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Anti -Exportin 4/XPO4 Rabbit PAb for Nuclear Receptor Research Antibody

Specification: 100uL
  • GB112617
  • Servicebio
  • Servicebio

Description

Product Information


Description

Exportin 4/XPO4 rabbit polyclonal

Protein full name

Exportin-4

Synonyms

Exp4, Xpo4, Kiaa1721

Immunogen

Recombinant protein corresponding to

Mouse Exportin 4/XPO4

Isotype

IgG

Purity

Affinity purification

Predicted MW.

130 kDa

Observed MW.

130 kDa

Uniprot ID

Q9ESJ0




Applications


Applications

Species

Dilution

Positive Tissue

WB

Mouse, Rat

1: 1000-1: 2000

C6, RAW264.7, PC12




Background


XPO4 belongs to a large family of karyopherins  that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments . In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.





Images


图片 1.png

Western blot analysis of XPO4 (GB112617) at dilution of 1: 2000

Lane 1: C6 cell lysate

Lane 2: RAW264.7 cell lysate

Lane 3: PC12 cell lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE: This product is intended for research only.

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