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Anti -WDR81 Rabbit pAb For WB

Specification: 100uL
  • GB112651
  • Servicebio
  • Servicebio

Description

Product Information


Description

WDR81 rabbit polyclonal

Protein full name

WD repeat-containing protein 81

Synonyms

Wdr81

Immunogen

Recombinant protein corresponding to

Mouse WDR81

Isotype

IgG

Purity

Affinity purification

Predicted MW.

212 kDa

Observed MW.

65 kDa

Uniprot ID

Q562E7, Q5ND34, D4A929




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 1000-1: 2000

brain, cerebellum




Background


This gene functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (By similarity). May also be involved in maintenance of normal mitochondrial structure and organization.




Images


图片 1.png

Western blot analysis of WDR81 (GB112651) at dilution of 1: 2000

Lane 1: HepG2 cell lysate

Lane 2: U2OS cell lysate

Lane 3: 293 cell lysate

Lane 4: Mouse brain tissue lysate

Lane 5: Mouse cerebellum tissue lysate

Lane 6: Rat brain tissue lysate

Lane 7: Rat cerebellum tissue lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE: This product is intended for research only.

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