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Anti -ULBP2 Rabbit pAb Polyclonal antibody for WB

Specification: 100uL
  • GB112666
  • Servicebio
  • Servicebio

Description

Product Information


Description

ULBP2 rabbit polyclonal

Protein full name

UL16-binding protein 2

Synonyms

ALCAN-alpha, NKG2D ligand 2, N2DL-2, NKG2DL2, Retinoic acid early transcript 1H, N2DL2, RAET1H, ULBP2

Immunogen

Recombinant protein corresponding to

Human ULBP2

Isotype

IgG

Purity

Affinity purification

Predicted MW.

27 kDa

Observed MW.

37 kDa

Uniprot ID

Q9BZM5




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human

1: 500-1: 1000

Jurkat, K562, THP-1 




Background


ULBP2 is a human ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. The interaction with UL16 blocks the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. ULBP2 is expressed in various types of cancer cell lines and in the fetus, but not in normal tissues.




Images


图片 1.png

Western blot analysis of ULBP2 (GB112666) 

at dilution of 1: 1000

Lane 1: Jurkat cell lysate

Lane 2: K562 cell lysate

Lane 3: THP-1 cell lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE: This product is intended for research only.

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