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Anti -Integrin beta 3 Rabbit pAb for western blot IHC Primary antibody

Specification: 100uL
  • GB112253
  • Servicebio
  • Servicebio

Description

Product Information


Description

Integrin beta 3 rabbit polyclonal

Protein full name

Integrin beta-3

Synonyms

Platelet membrane glycoprotein IIIa, GPIIIa, CD61, ITGB3, GP3A

Immunogen

KLH conjugated Synthetic peptide

corresponding to Human Integrin beta 3

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cell membrane

Predicted MW.

87 kDa

Observed MW.

100 kDa

Uniprot ID

P05106, O54890, Q8R2H2




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

spleen, thymus, lung

IHC

Mouse, Rat

1: 1000-1: 2000

spleen, bone marrow




Background


Integrin beta-3, also named as CD61 and GPIIIa, is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin beta-3 recognize the sequence R-G-D in a wide array of ligands and the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen which leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. 




Images


Western blot analysis of Integrin beta 3 (GB112253) at dilution of 1: 1000

Lane 1: HUVEC cell lysate

Lane 2: U87 cell lysate

Lane 3: C2C12 cell lysate

Lane 4: HeLa cell lysate

Lane 5: Mouse spleen tissue lysate

Lane 6: Mouse thymus tissue lysate

Lane 7: Mouse lung tissue lysate

Lane 8: Rat thymus tissue lysate

Immunohistochemistry analysis of paraffin-embedded mouse bone marrow  using Integrin beta 3 (GB112253) at dilution of 1: 2000


Immunohistochemistry analysis of paraffin-embedded rat bone marrow using 

Integrin beta 3 (GB112253) at dilution of 1: 2000

Immunohistochemistry analysis of paraffin-embedded mouse spleen using 

Integrin beta 3 (GB112253) at dilution of 1: 2000




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE: This product is intended for research only.

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