PHONE

+86(027) 5111 3188

Share to:

Anti -Otx2 Rabbit pAb for IHC IF primary antibody

Specification: 100uL
  • GB112574
  • Servicebio
  • Servicebio

Description

Product Information

 

Description

Otx2 rabbit polyclonal

Protein full name

Homeobox protein OTX2

Synonyms

Orthodenticle homolog 2, Otx2, Otx-2, CPHD6, MCOPS5, Orthodenticle 2

Immunogen

Recombinant protein corresponding to

Mouse Otx2

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus

Uniprot ID

P80206, Q64201


 

Applications

 

Applications

Species

Dilution

Positive Tissue

IHC

Mouse, Rat

1: 1200-1: 2400

retina, fetal rat

IF

Mouse, Rat

1: 600-1: 1200

fetal rat brain, fetal rat eye


 

Background

 

The orthodenticle homeobox 2, encoded by OTX2 gene, is a key transcription factor in developmental processes. In particular, it is required for the early specification of the brain and the embryonic development of sensory organs, including the, pineal gland, pituitary gland, inner part of the ear, eyes, and optic nerve. In later stages, it is important for maintaining intact retina and brain function. In addition, it acts as a transcriptional repressor and a gatekeeper of myogenic and neuronal differentiation in medulloblastoma cells. OTX2 binds to the MyoD1 core enhancer through its homeobox domain and the remarkable repressor activity exhibited by the homeobox domain renders OTX2 transcriptionally repressive.

 


 

Images

 

Immunohistochemistry analysis of paraffin-embedded mouse retina using 

Otx2 (GB112574) at dilution of 1: 2400

Immunohistochemistry analysis of paraffin-embedded fetal mouse using 

Otx2 (GB112574) at dilution of 1: 2400

Immunohistochemistry analysis of paraffin-embedded fetal rat using 

Otx2 (GB112574) at dilution of 1: 2400

 

Immunofluorescent analysis of paraformaldehyde-fixed fetal mouse brain using Otx2 (GB112574) at dilution of 1: 1200

Immunofluorescent analysis of paraformaldehyde-fixed fetal rat eye using 

Otx2 (GB112574) at dilution of 1: 1200

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

 

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

downLoadImgLaboratory(1)Slice 13Slice 10Slice 12

Contact us

Quick Links

Product Category

Get In Touch

 5th Floor, 22 Building, Biopark, Gaoxin 2nd Road No. 388, East Lake High-Tech Developing Zone, Wuhan, Hubei, China 430079
 +86(027) 5111 3188
Copyright © 2021  Wuhan Servicebio Technology Co., Ltd.