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GB112462 Anti -UBE3A FLJ26981 HPVE6A Rabbit Polyclonal Antibody for IHC IF

Immunogen: Recombinant protein corresponding to Mouse UBE3A
Isotype: IgG
Purity: Affinity purification
ul:
  • GB112462
  • Servicebio

Description

Product Information


Description

UBE3A rabbit polyclonal

Protein full name

Ubiquitin-protein ligase E3A

Synonyms

HECT-type ubiquitin transferase E3A, Oncogenic protein-associated protein E6-AP, Ube3a, Renal carcinoma antigen NY REN 54, HPVE6A, FLJ26981

Immunogen

Recombinant protein corresponding to

Mouse UBE3A

Isotype

IgG

Purity

Affinity purification

Subcellular location

CytoplasmNucleus

Uniprot ID

Q05086O08759




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Human, Mouse, Rat

1: 100-1: 300

lung, brain, kidney, hippocampus, heart

IF

Human, Mouse, Rat

1: 500-1: 1000

lung cancer, ovarian cancer, lung, spleen, thymus




Background


UBE3A (ubiquitin-protein ligase E3A, AKA E6AP) is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the ARNTL/BMAL1, ARC, RAD23A, RAD23B, MCM7, annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Additionally, UBE3A may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. UBE3A also plays an important role in the regulation of the circadian clock. Defects in UBE3A are a cause of Angelman syndrome (AS).




Images



Immunohistochemistry analysis of paraffin-embedded mouse lung using 

UBE3A (GB112462) at dilution of 1: 300

Immunohistochemistry analysis of paraffin-embedded rat lung using 

UBE3A (GB112462) at dilution of 1: 300

Immunohistochemistry analysis of paraffin-embedded mouse brain using 

UBE3A (GB112462) at dilution of 1: 300

Immunohistochemistry analysis of paraffin-embedded mouse kidney using 

UBE3A (GB112462) at dilution of 1: 300

Immunohistochemistry analysis of paraffin-embedded rat hippocampus using UBE3A (GB112462) at dilution of 1: 300

Immunohistochemistry analysis of paraffin-embedded rat heart using 

UBE3A (GB112462) at dilution of 1: 300

Immunofluorescent analysis of paraformaldehyde-fixed human lung cancer using UBE3A (GB112462) at dilution of 1: 1000

Immunofluorescent analysis of paraformaldehyde-fixed human ovarian cancer using UBE3A (GB112462) at dilution of 1: 1000

Immunofluorescent analysis of paraformaldehyde-fixed rat lung using 

UBE3A (GB112462) at dilution of 1: 1000

Immunofluorescent analysis of paraformaldehyde-fixed rat spleen using 

UBE3A (GB112462) at dilution of 1: 1000

Immunofluorescent analysis of paraformaldehyde-fixed rat thymus using 

UBE3A (GB112462) at dilution of 1: 1000




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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