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GB112521 Anti -CIITA C2ta Mhc2ta Rabbit Polyclonal Antibody for IHC

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse CIITA
Isotype: IgG
Purity: Affinity purification
ul:
  • GB112521
  • Servicebio

Description

Product Information


Description

CIITA rabbit polyclonal

Protein full name

MHC class II transactivator

Synonyms

CIITA, C2ta, Mhc2ta, Class II transactivator, NLR family acid domain containing

Immunogen

KLH conjugated Synthetic peptide

corresponding to Mouse CIITA

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus

Uniprot ID

P79621




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Mouse

1: 1000-1: 2000

spleen, thymus




Background


This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion.




Images


Immunohistochemistry analysis of paraffin-embedded mouse spleen using 

CIITA (GB112521) at dilution of 1: 2000

Immunohistochemistry analysis of paraffin-embedded mouse thymus using 

CIITA (GB112521) at dilution of 1: 2000




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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