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GB112543 Anti -Claudin 1 SEMP1 Cldn1 ILVASC Rabbit Polyclonal Antibody

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse Claudin 1
Isotype: IgG
Purity: Affinity purification
ul:
  • GB112543
  • Servicebio

Description

Product Information


Description

Claudin 1 rabbit polyclonal

Protein full name

Claudin-1

Synonyms

Cldn1, SEMP1, CLD1, Senescence associated epithelial membrane protein 1, ILVASC

Immunogen

KLH conjugated Synthetic peptide

corresponding to Mouse Claudin 1

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cell membrane

Predicted MW.

23 kDa

Observed MW.

20 kDa

Uniprot ID

O95832, O88551, P56745




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

fetal liver, fetal kidney, testis, skin

IHC

Human

1: 800-1: 1600

colon cancer, lung cancer, para-cancer skin




Background


Claudins are a family of proteins that are the most important components of the tight junctions, where they establish the paracellular barrier that controls the flow of molecules in the intercellular space between the cells of an epithelium. 23 claudins have been identified. They are small (20-27 kilodalton (kDa)) proteins with very similar structure. They have four transmembrane domains, with the N-terminus and the C-terminus in the cytoplasm. Claudin-1 is expressed primarily in keratinocytes and normal mammary epithelial cells.




Images


Western blot analysis of Claudin 1 (GB112543) at dilution of 1: 1000

Lane 1: A431 cell lysate

Lane 2: A549 cell lysate

Lane 3: Mouse fetal liver tissue lysate

Lane 4: Mouse fetal kidney tissue lysate

Lane 5: Mouse testis tissue lysate

Lane 6: Mouse skin tissue lysate

Lane 7: Rat skin tissue lysate

Immunohistochemistry analysis of paraffin-embedded human colon cancer using 

Claudin 1 (GB112543) at dilution of 1: 1600

Immunohistochemistry analysis of paraffin-embedded human lung cancer using 

Claudin 1 (GB112543) at dilution of 1: 1600

Immunohistochemistry analysis of paraffin-embedded human para-cancer skin using Claudin 1 (GB112543) at dilution of 1: 1600




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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