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Anti -NPDC1 Rabbit pAb

  • Servicebio

Description

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Product Information

 

Description

NPDC1 rabbit polyclonal

Protein full name

Neural proliferation differentiation and control protein 1

Synonyms

NPDC-1, Npdc1, CAB1

Immunogen

Recombinant protein corresponding to

Mouse NPDC1

Isotype

IgG

Purity

Affinity purification

Predicted MW.

36 kDa

Observed MW.

54 kDa

Uniprot ID

Q64322

 


 

Applications

 

Applications

Species

Dilution

Positive Tissue

WB

Mouse, Rat

1: 500-1: 1000

brain

 


 

Background

 

NPDC-1 (Neural Proliferation Differentiation and Control-1) is expressed in neurons once they have stopped dividing and begun to differentiate. NPDC-1 is transported from the Golgi apparatus via vesicles before becoming internalized by endosomes at the cell membrane. NPDC-1 interacts with Cdk2, D-type cyclins, and the transcription factor E2F1. This interaction can lead to an increased replication time, and might have implications in final neural differentiation and apoptosis. NPDC-1 has been shown to colocalize with synaptic vesicle proteins: synaptophysin, synaptobrevin 2, and Rab3 GEP (Rab3 GTP/GDP exchange protein). One function of NPDC-1 is to regulate retinoic acid-mediated events by directly interacting with retinoid receptors.

 


 

Images

 

图片 1.png

Western blot analysis of NPDC1 (GB112503) 

at dilution of 1: 1000

Lane 1: Mouse brain tissue lysate

Lane 2: Rat brain tissue lysate

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

 

NOTE: This product is intended for research only.

 

 

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