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GB112489 Anti -CSK P50CSK Rabbit Polyclonal Antibody for WB

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse CSK
Isotype: IgG
Purity: Affinity purification
ul:
  • GB112489
  • Servicebio

Description

Product Information

 

Description

CSK rabbit polyclonal

Protein full name

Tyrosine-protein kinase CSK

Synonyms

C-Src kinase, Protein-tyrosine kinase MPK-2, p50CSK, Csk

Immunogen

KLH conjugated Synthetic peptide

corresponding to Mouse CSK

Isotype

IgG

Purity

Affinity purification

Predicted MW.

51 kDa

Observed MW.

51 kDa

Uniprot ID

P41240

 


 

Applications

 

Applications

Species

Dilution

Positive Tissue

WB

Human

1: 250-1: 500

Jurkat, A549, Raji

 


 

Background

 

All members of the Src gene family of tyrosine kinases are characterized by a carboxy terminal domain tyrosine which is highly phosphorylated in the inactive form of the enzyme and phosphorylated to a much lesser extent when the enzyme is active. In the case of Src p60, Y527 is this tyrosine; however, a mutant form of c-Src in which Y527 is replaced by phenylalanine is transforming and displays 5- to 10-fold elevated kinase activity compared to its normal counterpart. Csk has been identified as a Src-related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as carboxy terminal regulatory sequences. Csk phosphorylates Src on Y527 and also downregulates Lyn, Fyn and Lck by tyrosine phosphorylation of carboxy terminal regulatory sites.

 


 

Images

 

图片 1.png

Western blot analysis of CSK (GB112489) 

at dilution of 1: 500

Lane 1: Jurkat cell lysate

Lane 2: A549 cell lysate

Lane 3: Raji cell lysate

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

 

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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