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GB111760 Anti -SOCS7 Nap4 Rabbit Polyclonal Antibody for IHC IF

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Immunogen: Recombinant protein corresponding to Mouse SOCS7
Isotype: IgG
Purity: Affinity purification
Volume:
Availability:
  • GB111760
  • Servicebio

Product Information


Description

SOCS7 rabbit polyclonal

Protein full name

Suppressor of cytokine signaling 7

Synonyms

SOCS-7, Socs7, Cish7, Nap4, Ash and phospholipase C gamma-binding protein, SOCS6

Immunogen

Recombinant protein corresponding to Mouse SOCS7

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cell membrane, Cytoplasm, Nucleus

Uniprot ID

Q8VHQ2




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Rat

1: 650-1: 1300

hippocampus, heart, testis

IF

Rat

1: 400-1: 700

brain, heart




Background


SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.




Images


Immunohistochemistry analysis of paraffin-embedded rat testis using

SOCS7 (GB111760) at dilution of 1: 1000

Immunohistochemistry analysis of paraffin-embedded rat hippocampus using

SOCS7 (GB111760) at dilution of 1: 1000

Immunohistochemistry analysis of paraffin-embedded rat heart using

SOCS7 (GB111760) at dilution of 1: 1000

Immunofluorescent analysis of paraformaldehyde-fixed rat brain using

SOCS7 (GB111760) at dilution of 1: 650

Immunofluorescent analysis of paraformaldehyde-fixed rat heart using

SOCS7 (GB111760) at dilution of 1: 650




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer(G2025).

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