English
Product Information
Description | SOCS7 rabbit polyclonal |
Protein full name | Suppressor of cytokine signaling 7 |
Synonyms | SOCS-7, Socs7, Cish7, Nap4, Ash and phospholipase C gamma-binding protein, SOCS6 |
Immunogen | Recombinant protein corresponding to Mouse SOCS7 |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location | |
Uniprot ID |
Applications
Applications | Species | Dilution | Positive Tissue |
IHC | Rat | 1: 650-1: 1300 | hippocampus, heart, testis |
IF | Rat | 1: 400-1: 700 | brain, heart |
Background
SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Images
| Immunohistochemistry analysis of paraffin-embedded rat testis using SOCS7 (GB111760) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded rat hippocampus using SOCS7 (GB111760) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded rat heart using SOCS7 (GB111760) at dilution of 1: 1000 |
| Immunofluorescent analysis of paraformaldehyde-fixed rat brain using SOCS7 (GB111760) at dilution of 1: 650 |
| Immunofluorescent analysis of paraformaldehyde-fixed rat heart using SOCS7 (GB111760) at dilution of 1: 650 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
