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Anti -Lrp2 / Megalin Rabbit pAb

  • Servicebio

Description

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Product Information


Description

Lrp2 / Megalin rabbit polyclonal

Protein full name

Low-density lipoprotein receptor-related protein 2

Synonyms

LRP-2, Glycoprotein 330, gp330, Megalin, Lrp2, Calcium sensor protein, DBS

Immunogen

Recombinant protein corresponding to

Mouse Lrp2 / Megalin

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cell membrane

Uniprot ID

A2ARV4, P98158




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Mouse, Rat

1: 500-1: 1000

kidney




Background


The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones.




Images


Immunohistochemistry analysis of paraffin-embedded mouse kidney using

Megalin (GB112109) at dilution of 1: 1000

Immunohistochemistry analysis of paraffin-embedded rat kidney using

Megalin (GB112109) at dilution of 1: 1000




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE: This product is intended for research only.


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