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GB112138 Anti -GDF 5 BMP 14 Rabbit Polyclonal Antibody for WB

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse GDF 5
Isotype: IgG
Purity: Affinity purification
ul:
  • GB112138
  • Servicebio

Description

Product Information


Description

GDF 5 rabbit polyclonal

Protein full name

Growth/differentiation factor 5

Synonyms

GDF-5, Bone morphogenetic protein 14, BMP-14, Gdf5, Bmp14, Bp, Gdf-5

Immunogen

KLH conjugated Synthetic peptide

corresponding to Mouse GDF 5

Isotype

IgG

Purity

Affinity purification

Predicted MW.

55 kDa

Observed MW.

55 kDa

Uniprot ID

P43026, P43027




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse

1: 500-1: 1000

NIH3T3, U87-MG




Background


Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction . Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG . Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 .




Images


图片 1.png

Western blot analysis of GDF 5 (GB112138)

at dilution of 1: 1000

Lane 1: NIH3T3 cell lysate

Lane 2: U87-MG cell lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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