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GB112162 Anti -TPOR MPL CD110 Mpl Rabbit Polyclonal Antibody for IHC

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse TPOR
Isotype: IgG
Purity: Affinity purification
ul:
  • GB112162
  • Servicebio

Description

Product Information


Description

TPOR/MPL rabbit polyclonal

Protein full name

Thrombopoietin receptor

Synonyms

TPO-R, Myeloproliferative leukemia protein, Proto-oncogene c-Mpl, CD110, Mpl, Tpor, MPLV, THCYT2

Immunogen

KLH conjugated Synthetic peptide

corresponding to Mouse TPOR

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cell membrane, Cytoplasm

Uniprot ID

Q08351




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Mouse

1: 500-1: 1000

kidney




Background


The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.




Images


图片 1.png

Immunohistochemistry analysis of paraffin-embedded mouse kidney using

TPOR (GB112162) at dilution of 1: 1000




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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