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GB112164 Anti -P2Y12 ADPG R Platelet ADP Receptor Rabbit Polyclonal Antibody for WB IHC

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse P2Y12
Isotype: IgG
Purity: Affinity purification
ul:
  • GB112164
  • Servicebio

Description

Product Information


Description

P2Y12 rabbit polyclonal

Protein full name

P2Y purinoceptor 12

Synonyms

ADP glucose receptor, ADPG-R, Purinergic receptor P2RY12, Platelet ADP receptor, HORK3, BDPLT8, P2Y12, P2ry12

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse P2Y12

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cell membrane

Uniprot ID

Q9CPV9




Applications


Applications

Species

Dilution

Positive Tissue

WB

Mouse, Rat

1: 250-1: 500

spinal cord, brain

IHC

Mouse

1: 1000-1: 2000

spinal cord, cerebellum



Background


The P2Y receptor family are G protein-coupled receptors which mediate the effects of extracellular nucleotides, primarily through the activation of phospholipase C. To some extent, the P2Y receptors can also activate potassium channels or, alternatively, inhibit adenylate cyclase and N-type calcium channels in response to extracellular nucleotides. Human platelets express two G protein-coupled nucleotide receptors, P2Y1 and P2Y12. P2Y12 is a receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. P2Y12 is an integral membrane protein involved in platelet aggregation. It is highly expressed in platelets, with lower levels in the brain, lung, appendix, pituitary and adrenal gland.




Images


image.png

Western blot analysis of P2Y12 (GB112164) 

at dilution of 1: 500

Lane 1: NIH3T3 cell lysate

Lane 2: RAW264.7 cell lysate

Lane 3: Mouse brain tissue lysate

Lane 4: Rat spinal cord tissue lysate

图片 1.png

Immunohistochemistry analysis of paraffin-embedded mouse spinal cord using

P2Y12 (GB112164) at dilution of 1: 2000

图片 2.png

Immunohistochemistry analysis of paraffin-embedded mouse cerebellum using

P2Y12 (GB112164) at dilution of 1: 2000




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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