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Anti -FOXK1/MNF Rabbit pAb

  • Servicebio

Description

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Product Information


Description

FOXK1/MNF rabbit polyclonal

Protein full name

Forkhead box protein K1

Synonyms

Myocyte nuclear factor, MNF, Foxk1, Fork head, FHX

Immunogen

Recombinant protein corresponding to Mouse FOXK1/MNF

Isotype

IgG

Purity

Affinity purification

Predicted MW.

75 kDa

Observed MW.

97 kDa

Uniprot ID

P85037





Applications


Applications

Species

Dilution

Positive Tissue

WB

Human

1: 500-1: 1000

HeLa, 293T, H1299




Background


The FOX family of transcription factors share a common DIUA binding domain termed a winged-helix or forkhead domain. Many FOX proteins play important roles in development, metabolism, cancer and aging. In skeletal muscles, undifferentiated myogenic stem cells (satellite cells) can mobilize to regenerate myofibers in response to injury. FOXK1 is expressed in these cells and regulates cell cycle progression through an interaction with its downstream target the cyclin-dependent kinase inhibitor p21 (CIP). Loss of FOXK1 in mice results in growth retardation and a severe impairment in skeletal muscle regeneration following injury. FOXK1 also shows expression in immature tissues of brain, eye, heart, lung and thymus.




Images


图片 1.png

Western blot analysis of FOXK1 (GB112183) at dilution of 1: 1000

Lane 1: HeLa cell lysate

Lane 2: 293T cell lysate

Lane 3: H1299 cell lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE: This product is intended for research only.



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