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Anti -Beclin-1 Rabbit PAb for IHC Primary Antibody

Specification: 100uL
  • GB11228
  • Servicebio
  • Servicebio

Description

Product Information

 

Description

Beclin1 rabbit polyclonal 

Protein full name

Beclin-1

Synonyms

BECN1, ATG6, NVPS30, beclin1, beclin-1, GT197

Immunogen

KLH conjugated Synthetic peptide

corresponding to Mouse Beclin1 

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm, Nucleus

Uniprot ID

Q14457


 

Applications

 

applications

species

dilution

Positive tissue

IHC

Human

1: 500-1: 1500

tonsil


 

Background

 

 

Plays a central role in autophagy . Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 . Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis . Protects against infection by a neurovirulent strain of Sindbis virus. May play a role in antiviral host defense.

 


 

Images

 

 

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Immunohistochemistry analysis of paraffin-embedded human tonsil using Beclin1(GB11228) at dilution of 1:1200

 


 

Storage

 

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

 


 

NOTE: This product is intended for research only.

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